Oak Ridge National Lab highlights our work on the mechanisms of global genome nucleotide excision repair: “Summit Supercomputer Draws Molecular Blueprint for Repairing Damaged DNA”. Related articles: Yu, J., Yan, C., Paul, T. et al. Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair. Nat Commun 15, 8511 (2024). Yu, J., Yan, C., Dodd, T. et […]
Oak Ridge National Lab highlights our recent work on the mechanisms of transcription-coupled nucleotide excision repair: “Decoding the Role of CSB Protein in DNA Repair“. Below is a recent video recording on the same topic:
Congratulation to Chunli Yan and Tom Dodd who published a new paper in the journal Nature Structural & Molecular Biology on the molecular architecture and functional dynamics of the transcription preinitiation complex (PIC). Yan, C.; Dodd, T.; Tainer, J.A.; He, Y.; Tsutakawa, S.E.; & Ivanov, I.* Transcription preinitiation complex structure and dynamics provide insight into genetic diseases Nature Structural […]
Our project on transcription pre-initiation complexes was highlighted by the Texas Advanced Computing Center. https://www.tacc.utexas.edu/-/how-to-see-living-machines
Our project on transcription pre-initiation complexes was picked up by the Science360 site of the National Science Foundation. https://news.science360.gov/archives/20160513/
An unprecedented molecular view of the critical early events in gene expression, a process essential for all life, has been provided by researchers at Georgia State University, the University of California at Berkeley and Northwestern University. Source: Researchers unveil new, detailed images of DNA transcription
An unprecedented molecular view of the critical early events in gene expression, a process essential for all life, has been provided by researchers in a new study. Cryo-electron microscopy (cryo-EM), a technique that studies samples at cryogenic temperatures, combined with state-of-the-art computational modeling, allowed researchers to visualize large transcription pre-initiation complexes (PIC) at near-atomic resolution. […]
The Journal of Computational and Structural Biotechnology has just published our invited review paper ‘Integrative Modeling of Macromolecular Assemblies from Low to Near-Atomic Resolution’.
Integrative Biomolecular Modeling 