Researchers Show How Proteins Help DNA Replicate Past a Damaged Site
Computation and experiment reveal how protein switching provides right tool for the job Source: Researchers Show How Proteins Help DNA Replicate Past a Damaged Site
Tag: DNA Damage Response
Supercomputers Simulate the Molecular Machines that Replicate and Repair DNA
Scientists use Jaguar to model replisome components to understand their role in health and disease. Source: Supercomputers Simulate the Molecular Machines that Replicate and Repair DNA
Georgia State scientist gets $1.675 million to study link between cancer and DNA replication, repair
Ivaylo Ivanov, associate professor of chemistry at Georgia State University, has received a five-year, $1.675 million federal grant to study how problems with DNA replication and repair may lead to cancer susceptibility and inheritable genetic diseases. Source: Georgia State scientist gets $1.675 million to study link between cancer and DNA replication, repair
Neutrons help shed light on critical protein activity that protects our DNA
“New study provides a framework for understanding how protein works and how it stimulates the DNA processing machines” Source: Oak Ridge National Laboratory
A new 5-year R01 grant awarded by NIGMS
The National Institute of General Medical Sciences (NIGMS) has funded our project “Integrative Modeling of PCNA Assemblies Engaged in Genome Duplication and Repair” as a 5-year R01 grant.
Another paper in Structure
Another paper, ‘Functional Dynamics in Replication Protein A DNA Binding and Protein Recruitment Domains’ has also appeared in Structure.
Our paper on PCNA posttranslational modification published in Structure
Our paper ‘Structurally Distinct Ubiquitin- and Sumo-Modified PCNA: Implications for Their Distinct Roles in the DNA Damage Response’ has been published by the journal Structure.
Another paper in Nucleic Acids Research
Our paper ‘Opening Pathways of the DNA Clamps Proliferating Cell Nuclear Antigen and Rad9-Rad1-Hus1’ has just been accepted by the journal Nucleic Acids Research. The recently solved structures of the DNA clamp protein 9-1-1 led to competing proposals regarding how 9-1-1 is loaded onto DNA. Through detailed subunit interface analysis, we identified the subunit interface […]
Our PNAS paper on PCNA ubiquitylation was highlighted
Our PNAS paper on PCNA ubiquitylation has been selected and evaluated by the post-publication peer review service Faculty of 1000 (F1000). According to the F1000 service this places our work in “.. the top 2% of published articles in biology and medicine”. The Oak Ridge Leadership Computing Facility at Oak Ridge National Laboratory highlights our […]
New PNAS paper on PCNA ubiquitination
Our collaborative efforts on PCNA ubiquitination with Berkeley Lab, Univ. of Iowa and Univ. of Delaware led to a combined experimental/computational publication currently in press in Proceedings of the National Academy of Science U.S.A.
Supercomputers Simulate the Molecular Machines that Replicate and Repair DNA
Scientists use Jaguar to model replisome components to understand their role in health and disease. Source: Supercomputers Simulate the Molecular Machines that Replicate and Repair DNA
Integrative Biomolecular Modeling 