Computation and experiment reveal how protein switching provides right tool for the job Source: Researchers Show How Proteins Help DNA Replicate Past a Damaged Site
Scientists use Jaguar to model replisome components to understand their role in health and disease. Source: Supercomputers Simulate the Molecular Machines that Replicate and Repair DNA
Ivaylo Ivanov, associate professor of chemistry at Georgia State University, has received a five-year, $1.675 million federal grant to study how problems with DNA replication and repair may lead to cancer susceptibility and inheritable genetic diseases. Source: Georgia State scientist gets $1.675 million to study link between cancer and DNA replication, repair
“New study provides a framework for understanding how protein works and how it stimulates the DNA processing machines” Source: Oak Ridge National Laboratory
The National Institute of General Medical Sciences (NIGMS) has funded our project “Integrative Modeling of PCNA Assemblies Engaged in Genome Duplication and Repair” as a 5-year R01 grant.
Another paper, ‘Functional Dynamics in Replication Protein A DNA Binding and Protein Recruitment Domains’ has also appeared in Structure.
Our paper ‘Structurally Distinct Ubiquitin- and Sumo-Modified PCNA: Implications for Their Distinct Roles in the DNA Damage Response’ has been published by the journal Structure.