Congratulation to group alumnus Dr. Max Xu and Dr. Chunli Yan and who published a new paper in the Journal of Molecular Biology that unravels the common origins of DNA clamp proteins’ subunit interface stability with implications for the function of these proteins in DNA replication. Perumal, S.K.; Xu, X.; Yan, C.; Ivanov, I. & Benkovic, S.J. Recognition of a […]
Scientists use Jaguar to model replisome components to understand their role in health and disease. Source: Supercomputers Simulate the Molecular Machines that Replicate and Repair DNA
“New study provides a framework for understanding how protein works and how it stimulates the DNA processing machines” Source: Oak Ridge National Laboratory
Another paper, ‘Functional Dynamics in Replication Protein A DNA Binding and Protein Recruitment Domains’ has also appeared in Structure.
Our paper ‘Opening Pathways of the DNA Clamps Proliferating Cell Nuclear Antigen and Rad9-Rad1-Hus1’ has just been accepted by the journal Nucleic Acids Research. The recently solved structures of the DNA clamp protein 9-1-1 led to competing proposals regarding how 9-1-1 is loaded onto DNA. Through detailed subunit interface analysis, we identified the subunit interface […]
Our paper ‘Probing DNA clamps with single-molecule force spectroscopy’ has just been published in Nucleic Acids Research and sheds light on the mechanisms of DNA clamp opening under external forces by combining molecular simulation with single-molecule micromanipulation experiments.
Our collaborative efforts with Berkeley/LBNL have led to a combined experimental/computational publication ‘Repair complexes of FEN1, DNA and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability’ currently in press in Proceedings of the National Academy of Science U.S.A.