Our group received a new INCITE Award from the U.S. Department of Energy Office of Science. The Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program accelerates scientific discoveries and technological innovations by awarding, on a competitive basis, time on the world’s fastest supercomputers to researchers with large-scale, computationally intensive projects that address “grand challenges” in science and engineering. Our research team will combine cryo-electron microscopy data and state-of-the-art computational modeling on the OLCF Summit supercomputer to elucidate the mechanisms of the nucleotide excision repair – a major pathway responsible for genome integrity.