NEW PAPER IN NATURE COMMUNICATIONS

Congratulations to Chunli Yan, Tom Dodd and Jina Yu who are co-authors on a just accepted paper in the journal Nature Communications. The paper is entitled “Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair.” Our integrative modeling study elucidates the mechanism by which Cockayne Syndrome B protein (CSB) binds to lesion-arrested RNA Polymerase […]

New INCITE Project Awarded for 2021

Our group received a new INCITE Award from the U.S. Department of Energy Office of Science. The Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program accelerates scientific discoveries and technological innovations by awarding, on a competitive basis, time on the world’s fastest supercomputers to researchers with large-scale, computationally intensive projects that address “grand challenges” in science and […]

New paper in Nature Communications

Congratulations to Tom Dodd who is the first author on a just accepted paper in the journal Nature Communications. The paper is entitled “Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path” and addresses a grand challenge for the DNA replication field by demonstrating through combined computational and biochemical analyses […]

DEPARTMENT OF ENERGY ISSUES A PRESS RELEASE ABOUT OUR 2020 INCITE AWARD

Our group was among the 47 recipients of INCITE Awards from the U.S. Department of Energy’s Office of Science. The projects originate in national laboratories, academia, and industry, and encompass a remarkable range of scientific inquiry. Ours was among the projects in the areas of Biological Sciences/Biophysics. Here are the 2020 INCITE Announcement and the list of 2020 […]

NEW PAPER IN NATURE STRUCTURAL & MOLECULAR BIOLOGY

Congratulation to Chunli Yan and Tom Dodd who published a new paper in the journal Nature Structural & Molecular Biology on the molecular architecture and functional dynamics of the transcription preinitiation complex (PIC). Yan, C.; Dodd, T.; Tainer, J.A.; He, Y.; Tsutakawa, S.E.; & Ivanov, I.* Transcription preinitiation complex structure and dynamics provide insight into genetic diseases Nature Structural […]

NEW PAPER IN THE JOURNAL OF MOLECULAR BIOLOGY

Congratulation to group alumnus Dr. Max Xu and Dr. Chunli Yan and who published a new paper in the Journal of Molecular Biology that unravels the common origins of DNA clamp proteins’ subunit interface stability with implications for the function of these proteins in DNA replication. Perumal, S.K.; Xu, X.; Yan, C.; Ivanov, I. & Benkovic, S.J. Recognition of a […]

NEW PAPER IN THE JOURNAL PCCP

Congratulation to Dr. Kathleen Carter who published a new paper in the jounal Physical Chemistry Chemical Physics detailing the mechanism of sequence-specific DNA binding of a designed small molecule binder DB2277. Carter, E.K.; Laughlin, S.; Dodd, T.; Wilson, W.D. & Ivanov, I* Small molecule binders recognize DNA microstructural variations via an induced fit mechanism Physical Chemistry […]

Department of Energy issues a press release about the 2019 INCITE Awards

Our group was among the 62 recipients of INCITE Awards from the U.S. Department of Energy’s Office of Science. The projects originate in national laboratories, academia, and industry, and encompass a remarkable range of scientific inquiry. Ours was among 8 projects in the areas of Biological Sciences/Biophysics awarded nationwide. Here are the 2019INCITEAnnouncement and the […]

GROUP MEMBERS PRESENT AT THE 2018 SERMACS MEETING IN AUGUSTA

Group members recently traveled to Augusta, GA to present at the 2018 Southeastern Regional Meeting of the American Chemical Society. Many thanks to all who presented! (Chunli Yan, Ashutosh Shandilya, Tom Dodd, Kurt Martin and Zhenyu Wang) At the meeting Ivaylo gave two invited talks: Emerging unified description of transcription initiation from cryo-EM and integrative computational […]

GROUP MEMBERS PRESENT AT THE ACS NATIONAL MEETING IN BOSTON

Group members recently traveled to Boston, MA to present at the 2018 National Meeting of the American Chemical Society. Ivaylo gave a talk entitled “Emerging unified description of transcription initiation from cryo-EM and integrative computational modeling ” in the COMP division (New Frontiers in Flexible Fitting, Image Processing & Refinement of Cryo-EM Data session). Many […]