Our INCITE Award was competitively renewed for 2023 by the DOE Office of Science. The Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program accelerates scientific discoveries and technological innovations by awarding, on a competitive basis, time on the world’s fastest supercomputers to researchers with large-scale, computationally intensive projects that address “grand challenges” in science and engineering. Our research team will continue to combine cryo-electron microscopy data and state-of-the-art  computation on the OLCF Summit supercomputer to elucidate the mechanisms controlling gene expression.