New INCITE Award provides access to the Oak Ridge Leadership Computing Facility

Ivaylo received a new INCITE Award from the DOE Office of Science. The Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program accelerates scientific discoveries and technological innovations by awarding, on a competitive basis, time on the world’s fastest supercomputers to researchers with large-scale, computationally intensive projects that address “grand challenges” in science […]

New Paper in the Journal Cell Discovery

Congratulation to Dr. Chunli Yan who published a new paper combining computational modeling and cryo-electron microscopy to unveil structures of pre-initiation complexes of RNA Polymerase III. Han, Y.; Yan, C.; Fishbain, S.; Ivanov, I. & He, Y. Structural visualization of RNA polymerase III transcription machineries. Cell Discovery (2018) (in press)

KEYSTONE SYMPOSIUM ON CRYO-EM

Ivaylo attended the 2018 Keystone Symposium “Cryo-EM from Cells to Molecules: Multi-Scale Visualization of Biological Systems” and presented our new findings on the transcription initiation by RNA polymerase I.

New Paper in the Journal eLife

Congratulation to Dr. Chunli Yan who published a new paper on combining computational modeling and Cryo-electron microscopy to uncover the mechanisms of transcription initiation. Han, Y.; Yan, C.; Nguyen, K.; Jackobel, A.; Ivanov, I.; Knutson, B.A.; He, Y. Structural mechanism of ATP-independent transcription initiation by RNA polymerase I. eLife (2017) 6, e27414, doi:10.7554/eLife.27414

New PNAS paper on FEN1/DNA clamp complexes

Our collaborative efforts with Berkeley/LBNL have led to a combined experimental/computational publication ‘Repair complexes of FEN1, DNA and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability’ currently in press in Proceedings of the National Academy of Science U.S.A.